Warning: array_shift() [function.array-shift]: The argument should be an array in /htdocs/public/www/config/ecran_securite.php on line 245
Methylphenidate : Gender trends in adult and pediatric populations over a 7 year period (article intégral) - addictovigilance.fr

Accueil du site > Articles publiés > 2017 > Methylphenidate : Gender trends in adult and pediatric populations over a 7 (...)

Methylphenidate : Gender trends in adult and pediatric populations over a 7 year period (article intégral)

Ehrhardt et al., Thérapie, 2017
  • Auteurs : C. Ehrhardt, Q. Boucherie, V. Pauly, D. Braunstein, E. Ronflé, X. Thirion, E. Frauger, J. Micallef.
  • Résumé :
    • Objective : Methylphenidate (MPH) is a prescription-stimulant medication which is authorized in France for two indications : attention-deficit hyperactivity disorder in children (aged ≥ 6 years) and narcolepsy in cases where modafinil is ineffective (for children and adults). MPH use has increased worldwide in the past 2 decades in children and adults. Different pharmacoepidemiological Europeans studies have described MPH patterns of use. To our knowledge, few pharmacoepidemiological studies have described MPH patterns of use in France.
    • Methods : In this context, we have performed a study on regional reimbursement database (PACA-Corse area, covering approximately 4 millions inhabitants). The first part of the study analyzed the evolution of MPH users characteristic’s yearly (grouped by age and gender) over a 7 year period (2005–2011). In order to better characterize patterns of MPH use in adults, a specific analyze has been performed in the second part on MPH adult users in 2011 with a gender descriptive approach.
    • Results : During the 7 year period, MPH dispensing grew from 0.28 to 0.68 patient per 1000. The proportion of adult patients rose from 14.8 to 25.7% (P < 0.0001), with patients mainly aged 35–49 years old. Gender differences in MPH users were noted between adults and children : the proportion of girls was less important in children than in adult (in 2011, 20.7% of girls among children vs 44.9% among adults). Moreover, the proportion of girls among children increased between 2005 to 2011 (15.1% of girls in 2005 versus 20.7% in 2011). Among adults, women were prescribed more antidepressants (41.5% versus 28.2%, P = 0.003) and less opiate maintenance treatments (22.4% versus 31.9%, P = 0.03) than men. Finally, 11% of men and 16.4% of women were over 50 years old.
    • Conclusion : MPH prescription greatly increased over 7 years, especially in adults. Moreover, in this population, patterns of MPH use differed with gender specificities. Such findings may increase clinical attention on monitoring MPH use in adults.
  • Référence : Therapie. Volume 72, Issue 6, December 2017, Pages 635-641.
  • Liens :

Dans la même rubrique